Home Business Bliss-inducing compound similar to marijuana may treat painful autoimmune disease

Bliss-inducing compound similar to marijuana may treat painful autoimmune disease

Bliss-inducing compound similar to marijuana may treat painful autoimmune disease

WASHINGTON — Might a marijuana-like drug that causes a blissful calm present new hope for folks affected by pores and skin lupus? Scientists from George Washington College say they’ve uncovered a compound that might function a brand new therapy for these coping with this extreme autoimmune pores and skin illness.

This research, based mostly on experiments with mice, has raised the chance that anandamide, the compound in query, may sooner or later assist alleviate the painful and disfiguring pores and skin lesions related to cutaneous lupus erythematosus.

Anandamide is classed as an endocannabinoid, and it acts on receptors in a way much like THC and CBD, that are the well-known lively elements of marijuana. Anandamide is without doubt one of the physique’s naturally produced cannabinoids, and it’s believed to play a job in regulating varied bodily programs, together with the immune system.

For the research, George Washington College researchers wished to see if they may harness the facility of anandamide to deal with and even forestall pores and skin lupus. The illness happens when the immune system mistakenly assaults wholesome pores and skin, leading to rashes and painful sores. Prior analysis has recommended that systemic lupus, a situation the place the immune system targets its own tissues and organs, is perhaps influenced by dysregulation of the human endocannabinoid system.

Image of intense inflammation in active lesion (left) and then after experimental treatment (right).
Picture of intense irritation in lively lesion (left) after which after experimental therapy (proper). (CREDIT: Adam Friedman/George Washington College)

To ship anandamide successfully by the pores and skin, researchers utilized nanoparticles that might progressively launch the experimental therapy. Collaborating with different scientists, they examined this supply system on genetically modified mice vulnerable to growing the pores and skin illness.

Within the preliminary section of the research, researchers administered anandamide enclosed in nanoparticles to mice that had not but displayed signs.

“We discovered that we may forestall pores and skin lesions from growing on the anticipated time level,” says Adam Friedman, professor and chair of the Division of Dermatology on the GW College of Medication & Well being Sciences, in a university release.

Subsequently, researchers investigated the therapy’s potential to alleviate signs in mice already experiencing the illness. They in contrast the consequences of anandamide encapsulated in nanoparticles with these of anandamide alone, given to a management group of mice. After 10 weeks, researchers noticed that the nanoparticle-based therapy considerably decreased the scale and severity of skin sores within the mice, surpassing the consequences of anandamide alone.

“If future research confirm these outcomes, the therapy may show to be a promising remedy for folks dealing with pores and skin lupus,” notes Friedman.

At the moment, docs primarily depend on steroids and different medicines to handle the illness, which don’t goal the underlying pathology.

“There’s an unmet want for a simpler therapy,” concludes Friedman.

The research is revealed within the journal Experimental Dermatology.

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